Research Questions:1.What role do environmental factors, immune system, nutritional patterns, obesity, and micronutrient deficiencies play in theincidence and prognosis of respiratory diseases? 2.What genetic predispositions are associated with increased risk or resilience to respiratory diseases? 3.How do coexisting systemic diseases, such as cardiovascular and metabolic disorders, interact with respiratory conditions?
Objectives:1.We aim to systematically examine the impact of environmental factors, immune system, nutritional patterns, and obesity on the theincidence and prognosis of respiratory diseases, utilizing the UK Biobank cohort. 2.We aim to identify genetic markers and potential gene-environment interactions associated with respiratory disease risk through advanced genomic analysis. 3.We will alsol investigate the interactions between respiratory and systemic illnesses, pinpointing common mechanisms and pathways.
Scientific rationale
Respiratory disorders constitute a substantial burden on world health, influenced by a complex interaction of genetic, environmental, and lifestyle variables, along with co-morbidities with other systemic diseases. Although previous studies have examined these elements individually, a holistic, integrative approach is still absent. This project will use the UK Biobank’s large dataset to use machine learning, multivariable regression, restrictive cubic splines, Bayesian kernel machine regression, weighted quantile sum regression, Shapley Additive Explanations, Mendelian randomization, and other causal inference techniques to figure out the complicated factors that affect respiratory health.The anticipated results encompass an enhanced comprehension of risk and protective factors, the identification of actionable intervention targets, and insights into disease mechanisms that may inform customized and public health policies.
