Heart failure is a serious health issue that impacts many individuals across the globe, but we still do not fully understand what causes it. Scientists have looked at protein levels in the body to study this. Typically, scientists’ study one protein at a time and its relationship to heart failure, but proteins interact with each other. By using a method called network analysis, researchers can study protein interactions to understand how they might contribute to heart failure, giving a better chance of finding ways to treat or prevent it. The aim of this study is to learn more about how certain proteins and their interactions might be linked to heart failure. We are particularly interested in finding out which pairs of proteins tend to change in people who develop heart failure compared to those who do not. Once we identify these protein pairs, we will study how they might work together to cause heart failure. We are also looking into which biological pathways these proteins are involved in and how they connect with other proteins in the body. Ultimately, we hope this will give us a clearer understanding of heart failure and help us find new ways to prevent it.
