Background:John Speakman’s article “Open Questions about the Causes of Obesity” published in the journal Science in 2023 suggests that obesity should be classified more rationally. Based on this, we also believe that the current classification of obesity is not detailed enough, and it is known that obesity often has complications such as cardiovascular disease and cerebrovascular disease. Based on this background, we believe that it is possible to combine obesity with diseases, so as to classify them according to comorbidities.
Principle:The common proteins between obesity and other diseases were searched, and they were classified by similar protein expression.
Method!COX survival analysis was performed based on UKB population data and UKB-PPP data, including age, gender, height, smoking, diet and other covariates, and proteins related to obesity and other diseases were screened. Finally, enrichment analysis was performed on other disease protein results and obesity protein results, and common proteins were screened as markers of susceptibility to different diseases.
Data:I need UKB whole queue data and UKB-PPP whole data.
