Cerebrovascular diseases, including stroke, transient ischemic attack, and vascular cognitive impairment, all are significant threat and substantial economic burden to global health, affecting individuals’ quality of life. Despite extensive research, the complex etiologies of these diseases, particularly concerning systemic factors, are not yet fully understood. By leveraging the UK Biobank’s comprehensive dataset, this study aims to investigate how systemic factors, such as genetic predisposition, lifestyle choices (smoking, diet, and physical activity), and environmental exposures, influence the onset, progression, and severity of cerebrovascular diseases. The research will employ a multi-omics approach to elucidate the intricate interplay between genetic factors and environmental influences in the development of these conditions. Integrating multi-omics analysis, including genomic, transcriptomic, proteomic, and metabolomic data, we aim to identify biomarkers and pathways driving cerebrovascular diseases. Ultimately, we seek to develop strategies for early detection, accurate diagnosis, and personalized treatment, thereby reducing the global burden of cerebrovascular diseases.
