Musculoskeletal disorders (MSDs), including diverse conditions affecting bones, joints, muscles, and connective tissues, pose a significant health challenge globally, impacting the lives of millions of individuals and carrying a substantial economic burden. Previous research has offered a range of interpretations regarding the underlying causes of MSD. We realize that not only demographic characteristics, living habits, environmental exposures and genetic characteristics can influence the occurrence of MSD, many comorbidities and chronic diseases of the heart, liver, intestines and brain also have an important impact on the susceptibility and development of MSD, which can be reflected by the biochemical indicators. Our study aimed to address these complexities and gaps by conducting a comprehensive, multi-dimensional, and long-term investigation into the trends of MSD. By examining these trends over the decades and exploring their connections with other relevant health conditions, our research provides valuable insights into the broader landscape of musculoskeletal health.
Our project is expected to last 36 months, and the causal evidence generated from the study will serve as a critical foundation for future research, healthcare strategies, and resource allocation, ultimately contributing to improved MSD prevention, management, and patient care. By staying proactive and responsive to these new challenges, healthcare systems can better serve the growing population affected by MSD.