Immune-mediated diseases constitute a clinically heterogeneous group of disorders which jointly affect 5-10% of the population in developed countries. Several immune mechanisms for immune mediated diseases are also involved in cancer and skin diseases, such as inflammation-promoting TH17 dominance, dysfunctional Treg surveillance, and microbiota cross talk between these diseases. Many cancers and skin diseases, for reasons that are not known, are increased in patients with immune-mediated diseases patients. Moreover, decreased or increased survival was observed in patients with both immune-mediated diseases and cancer. However, small sample size and conflict results highlight the significance of a population-based prospective studies to clarify the association of immune-mediated diseases with cancer and skin diseases in incidence and survival. This proposed study aims to investigate the association of immune-mediated diseases with cancer and skin diseases in incidence and survival. We expect to find that immune-mediated diseases are both associated with risk and survival in cancer. We also expect that immune-mediated diseases are both associated with risk and survival in skin diseases. We also expect that skin disease are associated with risk and survival in cancer and immune-mediated diseases. The estimated study duration of our project is 36 months.
