Research Background
Aging is a major key factor for various chronic diseases, increasing risk of disease and disability. It is a complex biological process and contributes to cellular and tissue dysfunction. As we age, the more likely we are to develop at least one age-related disease. To reduce the burden of this, it may be more effective to directly target the fundamental process of aging itself rather than treating individual disease. Several studies have been investigating aging at the molecular level to better understand. Researchers are looking for ways to slow or reverse aging to prevent or treat age-related disease and disability. However, little is known about how the human body changes molecularly with age at the tissue level. Since organs are composed of multiple tissues, each of which may age differently, understanding these changes at the tissue level is crucial for a comprehensive insight into the aging process.
Exercise is the most effective and closet intervention for mitigating aging effect, making physical activity essential as one gets older. Because it works on every physiological system and keeps your entire body fine-tuned. Such effects of exercise included bolstering the immune system, keeping the brain young, and slowing the ‘biological clock’.
This project will explore how exercise affects aging-related proteins and observe changes in these proteins over time after exercise. We hypothesized that comprehensive quantification of tissue-specific proteins in plasma would allow us to minimally invasive assessment and track human aging across all organs.
Research Objective
1. Identification exercise proteome signatures associated with reverse-aging
2. Identification of aging-related proteome changes
3. Identification of organ signatures associated with aging process