The prevalence of digestive system disease and chronic diseases is increasing. These diseases are often accompanied by chronic disabling conditions, which have significant socio-economic implications for individuals, healthcare systems, and society. A combination of genetics, environmental factors and lifestyle determine an individual’s risk of disease susceptibility. Advancing multi-omics technology allowing exploration of pathophysiological factors during the disease process, and the UK Biobank provides a wealth of information for us as a large dataset containing multi-omics, broad environmental exposure and clinical disease data. We propose this study to address a series of research questions in how a range of environmental risk factors are associated with digestive system diseases and chronic disease risk, prognosis and survival through multi-omics data. We explored the multi-omics signatures of digestive system and chronic diseases using genomics, proteomics, and metabolomics data. Obtaining disease-associated signature changes will help to elucidate the pathophysiological processes involved in disease development. We will map how common risk factors influence disease to gain inspiration for early prevention and clinical intervention. Our planned research aligns with the objectives of UK Biobank research, which aims to improve the prevention, diagnosis, and treatment of disease and promote the health of society as a whole. The findings of this work will provide solid evidence for the complex pathogenesis of digestive system and chronic diseases and for patient clinical practice.
