Pulmonary hypertension (PH) stands as a significant global health concern, affecting individuals across all age groups, with a higher prevalence among older demographics. This condition places notable strain on the heart, culminating in right ventricular failure and eventual mortality. Notably, recent global burden of disease studies has recognized PH as a contributor to mortality. However, comprehensive epidemiological data on PH remains scarce, particularly regarding vulnerable populations. The dynamic nature of PH epidemiology underscores the necessity for studies to explore risk factors and vulnerable demographics. Additionally, there is an urgent need to evaluate the prognosis of PH to mitigate potential comorbidities.
Our research endeavors to elucidate the relationship between PH incidence and various potential risk factors, aiming to discern causal associations. These factors encompass demographic and sociological traits (e.g., gender, education), lifestyle factors (such as physical activity, diet, and smoking habits), biomarkers (including troponin, brain natriuretic peptide, and N-terminal pro-brain natriuretic peptide), medical variables (such as medications), and genetic predispositions (including SNPs). Moreover, we seek to comprehend the impact of PH on associated comorbidities.
Our study, spanning three years and comprising approximately 500,000 participants, employs advanced statistical methodologies, including the Cox proportional risk model, Mendelian randomization, logistic regression, and restricted cubic splines, to explore the intricate associations between PH, its potential risk factors, and associated comorbidities.
In summary, our research aims to delineate causal risk factors and comorbidities linked with PH, thus advancing our understanding of its epidemiology and pathogenesis. Such insights will inform the development of more effective prevention, treatment, and management strategies for PH.