Rheumatoid arthritis (RA) is an autoimmune joint disease which results in considerable joint inflammation, pain, and stiffness. Individuals with RA typically experience worse symptoms in the morning (e.g. increased stiffness) which implies that there is a circadian (body clock) involvement. This research aims to gather a list of variants associated with RA using the literature and the GWAS catalog, and analyse how prevalent these variants are in the genomes of participants with RA in the cohort. This will be compared to a ‘control’ cohort, which are participants who do not have RA. The frequency of the mutations/variants in the two cohorts will be compared. Further analysis on this data will include if these variants are more common in individuals with RA, or if they are more common in the general population.
