Dementia is a global health challenge currently affecting over 55 million people worldwide. The incidence of dementia is decreasing in higher-income countries probably due to healthier lifestyles, suggesting that prevention is possible. Further reduction of dementia incidence can be achieved through structured prevention plans. There are non-modifiable and potentially modifiable risk factors that can contribute to dementia risk. Risk profiling of cognitively unimpaired individuals based on these risk factors can inform personalized and targeted prevention interventions. However, an accurate estimation of the contribution of each of these risk factors accounting for each other in representative populations is still lacking. Additionally, a cumulative risk assessment that combines lifestyle, biological, and genetic risk factors adjusted for each other remain to be developed. This study aims to accurately assess the adjusted hazard ratio of lifestyle, biological and genetic factors on dementia incidence in population-based cohorts of cognitively unimpaired individuals. The risk calculation will be conducted as a multi-centric study by analyzing pooled patient-level data sets collected from large population-based cohorts. This study will provide precise estimations of the adjusted risk of each risk factor which are pivotal for the calculation of the cumulative adjusted dementia risk for individuals. Our study will be used in the second-generation memory clinics (Brain Health Services) aimed at evidence-based and ethical dementia prevention in at risk cognitively unimpaired individuals. In the scope of the activities of BHS: (i) assessment of risk factors, (ii) risk communication, and (iii) risk reduction with multi-domain interventions; enabling enhancements in the risk profiling of cognitively unimpaired individuals will allow to reduce the global burden of dementia.
