Heart failure (HF), as a terminal cardiovascular disease, not only leads to a decline in the heart’s pumping function, but also may affect brain health through mechanisms such as low perfusion, cerebral small vessel disease, inflammation, and neuroendocrine abnormalities.Cognitive decline can seriously affect the compliance, quality of life and long-term prognosis of patients with heart failure. UK Biobank provides cognitive assessment, brain imaging and detailed health records, and is an ideal platform for exploring the association between heart failure and cognition, our research aims to analyze the multi-dimensional connection between heart failure and cognition. We will compare the performance differences between patients with heart failure and those without heart failure in multi-dimensional cognitive function tests, and explore the relationship between different subtypes of heart failure (such as HFrEF vs HFpEF) and cognitive dysfunction. Furthermore ,we will also explore whether heart failure is related to changes in brain structure in the subpopulation of brain MRI. Third, our research will compare the incidence and subtype manifestations of heart failure between patients with cognitive impairment and those without cognitive impairment. Fourth, our study will explore changes in blood pressure over time in patients with heart failure and non-heart failure, as well as its effects on cognitive function. Last, our study will analyze the moderating effects of the course of heart failure, comorbidities, and mental and psychological states (such as depression) on cognition. In the end, our project is able to provide important epidemiological evidence, offering an intervention window for the comprehensive management of patients with heart failure (including brain health) and guide cognitive screening and early intervention strategies for high-risk populations.
