Recent important studies have highlighted the crucial role played by the body’s immune system in Alzheimer’s disease. Changes in immune cells outside the brain are now thought to influence brain health, creating a link between the immune system and the brain.
Research questions: 1) What are the peripheral immune signatures specifically associated with brain pathology in Alzheimer’s disease, and what are their key regulatory mechanisms? 2) How can peripheral immune multi-omics data be utilized to identify core diagnostic biomarkers that are highly specific and sensitive to the early stages of Alzheimer’s disease, and capable of distinguishing it from other neurodegenerative disorders!
This project will carry out a detailed study of immune cells in the blood of people at different stages of Alzheimer’s. By using advanced lab techniques and computer analysis, we aim to: 1) Find early signs in the immune system that could help diagnose Alzheimer’s sooner. 2) Predict how the disease may progress. 3) Discover new ways to treat Alzheimer’s by targeting the immune system. Our goal is to improve early detection and to develop new treatments that could slow down or prevent the Alzheimer’s disease.
