Approved Research

A prospective study of daily lifestyle/living customary and the risk of breast cancer in the UK Biobank

Lay summary

The aim of our project (estimated duration: 2 years) is to investigate the effect of lifestyle on breast cancer risk and prognosis, and to evaluate the efficacy of separated or combined lifestyle interventions on the incidence and prognosis of female breast cancer and further explore the possible mechanisms more and more attention has been paid to the impact of daily lifestyle on the incidence and prognosis of breast cancer. Breast cancer is a complex disease resulting from a combination of genetic and environmental factors. Daily lifestyles were reported to be related to cancer risk and prognosis, including physical activity, electronic device use, sleep, smoking, diet habit, alcohol intake and sexual factors et al. Although some studies have explored and speculated on this issue, these researches are not in-depth enough and the results are controversial. Therefore, solid and thorough population researches of this issue are needed. We plan to discuss the lifestyle risk factors effect on breast cancer risk and prognosis separately according to the clinical characteristics, such as menstrual history, age, reproductive history, etc. Lifestyle risk factors can be stratified by severity, such as smoking and alcohol intake, time spent on electronics, and frequency of physical activity The study will provide lifestyle guidance for healthy people and breast cancer patients, provide strategies to prevent breast cancer and improve prognosis, reduce the incidence and mortality of breast cancer, and reduce the medical burden of social funds.