Approved Research

A retrospective cohort analysis regarding the association of childhood trauma experiences with bone health among UK biobank participants

Lay summary

Aims: Our research project aims to investigate the association between childhood trauma experience (measured by Childhood Trauma Screener) and bone health markers in adults, including bone-related serum markers and bone mineral density, through retrospective analyzing a large database cohort, thus to infer that whether childhood trauma experience has an association with bone health. We also aim to explore further which Childhood Trauma Screener subtype is associated with bone health.

Scientific rationale: Our previous research has found that the experience of childhood trauma impact bone health in adults, including reduced bone mineral density and dysregulated serum bone markers through animal and human studies. Now we try to take the research a step further, by analyzing the data from the UK Biobank database, we can explore the association between childhood trauma and bone health in a large cohort, updates our understanding of osteoporosis etiology, and open new avenues for personalized prevention and intervention strategies.

Project duration: The estimated duration of this project is 36 months.

Public health impact: The results of this study allow for additional beneficial outcomes for public health. By identifying potential associations with childhood trauma, the results of this study have the potential to provide early prevention strategies and increase awareness among healthcare practitioners, policymakers, and the public. Then will ultimately contribute to reducing the population's childhood trauma burden.