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Approved Research

Age and gender adjusted low serum apolipoprotein A1, high C-reactive protein as predisposing biomarkers of SARS-CoV-2 infection. A large retrospective study using UK biobank.

Principal Investigator: Professor Thierry Poynard
Approved Research ID: 79974
Approval date: March 18th 2022

Lay summary

The aim of this project is to validate a blood based risk stratification tool, combining existing and routinely available markers (apolipoprotein-a1, C-reactive protein) with age and gender that could be an additional diagnosis and prognosis tool for screening subjects at high-risk of SARS-Cov-2 infection (SI).

The 2 biomarkers have a published role in the SARS-Cov-2 infection, with normal values depending on age and gender. A score combining the values of the 2 assays, corrected by age and gender, will be correlated to the risk of SI.

The project will last 3 years.

The public health impact could be major, helping the clinicians stratifying the patients according to this novel risk score.