Approved Research

Age-related changes in DNA methylation patterns to predict drug targets in osteoarthritis

Lay summary

Around a third of the patients that receive knee replacement still have chronic pain after surgical knee replacement. We have evidence that this may be due to changes to their DNA that could be effective targets for drug development. We plan on comparing the DNA of patients with and without pain to identify the parts of the DNA that could lead us to the most important and relevant changes and lead us to an eventual treatment for those patients that have chronic pain.