Approved Research

Analysis of genetic, environmental, lifestyle and self-physical health risk factors for ocular complications in high myopia patients

Lay summary

The aim of our study is to investigate the genetic, environmental, lifestyle, and self-physical health factors associated with ocular disorders in individuals with high myopia and to develop a predictive model to assess the risk of ocular complications in such patients. The study is motivated by the lack of understanding of the underlying risk factors leading to complications associated with high myopia. To address this gap in knowledge, the study will leverage the extensive genetic and health data available in the UK Biobank to uncover new insights into the risk factors associated with high myopia complications. The research methodology involves several analytical approaches, including genetic analysis, logistic regression, multivariate analysis, and machine learning. The project is expected to last for three years.

The findings of this research could have a significant impact on public health by improving screening and management of high myopia, potentially reducing the incidence of vision loss. Moreover, the development of predictive models could enhance clinical decision-making and improve patient outcomes. Overall, this study has the potential to advance our understanding of high myopia and its complications, leading to better prevention and treatment options for this prevalent and potentially serious condition.