Background: The metabolic dysfunctions can result in the development of various associated metabolic diseases, including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and cancer. Genetic, environmental and lifestyle factors are the main risk factors on metabolic syndrome. However, the causal effects of the genetic, environmental or lifestyle factors and metabolic alterations remain to be elucidated.
Objective: This study aims to explore the causal associations between genetic, lifestyle or environmental factors and the risk of metabolic diseases using Mendelian randomization (MR) analysis.
Project duration: The duration of this project will be three years, from 2021-2023.
Public health impact: This research will provide important contributions to advance understanding of environmental, lifestyle or genomic influence and mechanisms underlying complex metabolic traits. We will finally build novel strategies for risk prediction in the common metabolic diseases.
