Approved Research

Association between early repolarization and cardiovascular outcomes and metabolic outcomes

Lay summary

Early repolarization pattern (ERP) is a common electrocardiographic variant manifested as elevation of  Q wave-R wave-S wave(QRS) junction (J-point) and QRS notching or slurring in multiple leads. Although it has long been considered a benign phenomenon, more recent studies have demonstrated positive association between an ERP and various end points, including ventricular fibrillation (VF) and sudden cardiac death (SCD). We aim to assess the long term prognosis associated with ERP in middle aged and elderly population, in order to help guide clinical prevention decisions. This research project will last for 3 years. The result would prove that early repolarization might be promising a marker of  cardiovascular risk in the general population, and repeated measurements of the early repolarization should be implemented in general population to assist in risk stratification and assessment.