We aim to investigate the impact of lifestyle, genetic factors and their interaction with the incidence of skin cancers. Previous literature has suggested that physical activity is protective against various cancer types in both smokers and non-smokers. However, systemic exploration of how the beneficial influence of physical activity might be attenuated or strengthened by genetic background is limited. With the large sample size of UK Biobank, we will have sufficient power to characterize this potential interaction. In addition, blood biochemistry markers have been a proxy for organ function and widely used in the clinic. We would like to investigate whether these markers can be used to inform the interaction between lifestyle factors and genetic composition.