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Approved research

Association of nutrient composition with metabolic syndrome and cardiovascular risk - Findings from the UK Biobank

Principal Investigator: Professor Mathias Fasshauer
Approved Research ID: 53438
Approval date: November 5th 2019

Lay summary

Nutrition plays a key role in the prevention and treatment of obesity which is associated with metabolic disease including type 2 diabetes mellitus and cardiovascular disease. Extensive studies exist on total macronutrient intake in relation to obesity and metabolic health. However, there is a growing body of evidence that nutrient composition, i.e. relative distribution and components of nutrients consumed, rather than total macronutrient consumption affects metabolic and vascular health. Therefore, the present project assesses whether nutrient composition is associated with: - Features of the metabolic syndrome and vascular disease (cross-sectional study; aim 1). - Incidence of specific health-related outcomes (prospective study; aim 2). - All-cause and disease-specific mortality (prospective study; aim 3). The present project will contribute to evidence-based recommendations on optimal dietary patterns and food composition to prevent metabolic and vascular disease. Therefore, the research project is in line with the aims of UK biobank, i.e. to improve the prevention of serious public health risks like metabolic syndrome and cardiovascular disease.