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Approved Research

Association of triglyceride-glucose (TyG) index with incidence of hypertension

Principal Investigator: Dr Javad Alizargar
Approved Research ID: 73887
Approval date: March 7th 2022

Lay summary

Aims: To know if different levels of triglyceride-glucose (TyG) index is associated with incidence of hypertension in individuals.

scientific rationale: Insulin resistance has been recognized to play a significant role in many diseases that involve heart and vessels. TyG index is a marker of insulin resistance. As insulin resistance is a predictor of diabetes and diabetes has a high association with new onset hypertension, TyG might be an independent predictor of new onset hypertension.

project duration: After getting access to the database, data cleaning based on inclusion and exclusion criteria, final data will be prepared for analysis (1 month). Data analysis by our data scientists consists of general categorization and simple statistics followed by advanced statistical analysis (2 months). After getting the main results preparing the report and preparation of the manuscript to submit to scientific journals (2 months).

public health impact: By knowing if the insulin resistance index can be an independent factor for development of hypertension, we can set cut of values to warn people at risk and improve the adverse health outcome of hypertension.