Approved Research

Associations Between Glycolipid Metabolism and Major Adverse Cardiovascular Events with Modifiable Lifestyle Factors as Mediators: Moderated Mediation Analyses based on UK Biobank

Lay summary

Cardiovascular disease (CVD) remains the most common cause of death globally and abnormal glycolipid metabolism greatly increases the risk of major adverse cardiovascular events (MACEs). People with abnormal glycolipid metabolism, especially those who have a diagnosis history of hyperlipidemia or diabetes, usually change their lifestyles according to the doctor's advice, and therefore reduce the risk of MACEs. Therefore, modifiable lifestyle factors are likely to play a mediating role in the association between glycolipid metabolism and MACEs. Furthermore, the associations mentioned above might also vary in different strata or levels by demographic characteristics. Hence, we aim to evaluate the mediating role of modifiable lifestyle factors between glycolipid metabolism and MACEs and we hypothesize these associations are moderated by demographic characteristics. Findings from this research would provide valuable references for relevant healthy organizations to formulate healthy policies and guidelines as well as provide more practical, effective and personalized lifestyle advice for population with different demographic characteristics.