Associations of genetic factors, healthy lifestyle behavior, testosterone level and sleep traits with human healthspan
Life expectancy has increased dramatically since the last century, while the quality of life for the elderly has not increased proportionally. These challenges call for longevity research to focus on understanding the pathways controlling healthspan.
Previous studies have found that endogenous testosterone concentrations, lifestyle behaviors, and sleep traits are associated with the risk of various cancers and chronic diseases, while the relationship between them and healthspan is still unknown.
Complex mechanisms driven by a combination of genetic, environmental, and lifestyle factors cause differences in individual healthspan. UK Biobank cohort, a large dataset with both environmental exposures and genomics data, has an incomparable advantage to systematically identify the risk factors for short healthspan.
We estimate that we will complete the majority of data analysis and finish the publication of the relevant results in 18 months. For these aims, we propose to:
1. investigate the associations and the causal relationships between testosterone level, sleep traits, healthy lifestyle index (HLI), and healthspan;
2. develop a polygenic risk score (PRS) for human healthspan based on reported healthspan-associated genetic variants;
3. use the above results to generate a health prediction model to establish new strategies for extending healthspan.
Our study will help to promote the understanding of aging and longevity, and the model could be used in identifying groups of individuals who are at high risk of short healthspan and more likely to benefit from interventions.