Associations of Lifestyle, Environmental factor, Genetic Risk with Aging-related Diseases

Xiangya Hospital of Central South University

Lay summary

Past researchers have demonstrated that genetic factors can increase the risk of aging-related diseases such as multiple cancers, cardiovascular and respiratory diseases and so on. Distinct genes have been identified as genetic factors for specific aging-related diseases through genome-wide scanning. Moreover, the results of studies based on a large population had shown that the risk of aging-related diseases could also be influenced by lifestyle and environment. However, the potential interaction between genetic variants, environment and lifestyle on these aging-related diseases has not been thoroughly investigated. So, we want to conduct this study to examine that if adherence to a healthy lifestyle and improvement of environmental situation can offset genetic risk for aging-related diseases.

The estimated duration of this project is 36 months. We expect to find an interaction between genetic risk, environment and lifestyle in aging-related diseases and to remind the public of resisting the genetic risk of aging-related disease by changing specific lifestyles and improving the environment.