Approved Research

Brain morphometry and functional network connectivity across sexes in the healthy ageing population.

Lay summary

We aim to investigate if sex plays a significant role in structure and functional connectivity of the brain in a healthy aging population of Indian origin.Using structural and functional magnetic resonance imaging (MRI), we will measure brain size, volume, and form, as well as the strength of association between and within brain regions with regard to functionality. Previous research conducted in our lab emphasizes the importance of considering sex as a contributing factor in brain data analysis.We would like to explore participant data of Indian origin as there is limited research in this area. Other influencing factors such as age, total brain volume, education, biochemistry (role of hormones), handedness and physical activity would be used as nuisance variables. We'll use a machine learning algorithm to train the dataset at our lab and test the UK Biobank data using the features obtained while training (The algorithm learns from known data to make predictions or classifications on new unseen dataset. )

Understanding potential sex related differences with or between the left and right brain functions can shed light on various cognitive abilities such as memory, attention, creativity etc. It can also reveal any influences of structure on functional connectivity between sexes.Our previous study on left and right brain dominance between sexes, we found that the idea that men are more logical and analytical which is associated with the left brain function while women are more intuitive and creative which is associated with the right brain functions. This breaks stereotypes and identifies the unique capabilities of each sex. Stronger connectivity in specific brain regions in males or females may be associated with cognitive or behavioral aspects more pronounced in that respective sex.

The influence of biological sex brings numerous benefits to communal health. It allows for the identification of sex-specific health risks, evidence-based health policies, and equal access to healthcare.  Recognizing the impact of biological sex on disease prevalence and outcomes enhances disease surveillance efforts, leading to more effective interventions and prevention strategies. Furthermore, the unique needs and strengths associated with each sex allows for informed parenting practices and educational approaches, promoting optimal child development and reducing gaps. Incorporating this knowledge into social program strategies helps address sex-specific issues and better support individuals. Exploring brain differences between sexes can also guide interventions for mental well-being and detect modifiable changes if any.