Approved Research

Brain structure and connectivity - links to metabolic health and diabetes

Lay summary

Our body's metabolism is regulated by a complex interaction between the brain and peripheral organs, such as the liver, muscles, and adipose tissue. Research over the years has shown that the human brain can regulate metabolism in the peripheral organs through specific signaling pathways. Impairments in these regulatory mechanisms can contribute to the development of metabolic diseases such as diabetes and obesity.

In a new analysis of UKBB data, we aim to investigate the links between the core hubs of brain anatomy, structure, and connectivity focused on the hypothalamus which are linked to metabolism, focusing on pre-diabetes and diabetes, including novel subgroups of diabetes. We will also investigate adiposity and body fat distribution in a cross-sectional as well as a longitudinal manner. Our research will involve linking brain imaging data from the UK Biobank, to clinical, laboratory, and genetic data. We will explore the functional and anatomical connections between brain regions involved in metabolic regulation, with a particular focus on the hypothalamus, which plays a critical role in regulating glucose and energy metabolism.

The research will also investigate how environmental factors such as diet and exercise modulate links between the brain and whole-body metabolism. This information could be valuable in developing interventions aimed at promoting healthy lifestyles and preventing metabolic diseases.

Our analyses are of significant public interest as metabolic diseases are a growing public health concern worldwide, affecting millions of people and placing a significant burden on healthcare systems. The research has the potential to advance our understanding of metabolic diseases and could contribute to new approaches for their prevention and management. It could ultimately contribute to improving public health and reducing the burden of metabolic diseases on individuals and healthcare systems.

The UK Biobank is a valuable resource for this research, providing a large and diverse cohort of participants, including individuals with varying degrees of metabolic health. By linking brain and whole body magnetic resonance imaging data to clinical, laboratory, and genetic data from this cohort, our research has the potential to provide a more comprehensive understanding of the complex interplay between brain metabolism and peripheral organs.

In summary, our research aims to provide critical insights into brain mechanisms underlying metabolic diseases such as diabetes and obesity.