Approved Research

Causal relationships between different exposures and major metabolic and cardiovascular diseases

Lay summary

Noncommunicable diseases including metabolic and cardiovascular diseases, including obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), metabolic syndrome, and coronary heart disease (CHD), account for more than 70% of the deaths worldwide. A variety of exposures, including dietary habits, exercise behavior, smoking, alcohol consumption, nutrient intake, beverage intake and sleep are related with the risk of these diseases. Thus, it is imperative to develop better strategies to reduce the morbidity and mortality of major metabolic and cardiovascular diseases by determining the causal associations between different exposures and major outcomes.

We aim to explore the associations between different exposures and metabolic and cardiovascular disease in a large population-based cohort study. Our project will provide evidence for developing efficient strategies to reduce morbidity and mortality of metabolic and cardiovascular diseases. This project is expected to last for 36 months. The findings may deepen the understanding of associations between different exposures and metabolic and cardiovascular diseases and their related outcomes, and may provide strong evidence for the prevention and therapeutic strategy of metabolic and cardiovascular diseases, and even make a significant contribution to global public health.