Approved Research

Causal research on genetic factors and lifestyle habits in relation to various chronic diseases

Lay summary

There is a universal causal relationship between lifestyle habits such as diet, physical activity, and social engagement, and several globally prevalent chronic diseases including dementia, cardiovascular and cerebrovascular diseases, diabetes, kidney diseases, gynecological diseases and cancers. By understanding these causal connections and assessing their risks comprehensively, we can gather evidence for the prevention and treatment of chronic diseases. However, it is important to note that these diseases are also closely associated with genetic factors. The complexity of studying causal relationships is further compounded by confounding factors in cross-sectional or retrospective cohort studies. To overcome this challenge, we propose employing Mendelian randomization methods to establish causal relationships specifically between various lifestyle habits and chronic diseases.

This project aims to explore the causal effects of lifestyle factors (such as diet, behavior patterns, and natural environment) and health attributes (including psychological conditions, blood markers, physical measurements, and medical history) on chronic diseases. By incorporating genetic factors and utilizing Mendelian randomization models, we will evaluate the causal effects, mediation effects, and dose-response relationships through various models, including linear models and composite nonlinear models. The ultimate goal is to enhance the understanding of the causal relationship between lifestyle habits and chronic diseases. The conclusions drawn from this research will help healthcare professionals improve chronic diseases by adjusting daily lifestyle behaviors. The duration of this project will be 36 months, and we plan to utilize the entire cohort sample.