Characterization of risk factors and biomarkers for digestive tract diseases
The digestive tract is important in maintaining the function of the human body. Diseases of the organs in the digestive tract are harmful to our health. In recent years, different methods with promising therapeutic effects have been developed to treat digestive tract diseases. Despite advances in therapeutics, digestive tract diseases can lead to serious consequences and long-lasting burdens. Thus, "the best fight is the one you avoid", the prevention and prediction of digestive tract diseases are as important as treating them. Individual characteristics, such as lifestyles, psychological factors and genetic variations, could have far-reaching impacts on the development of digestive tract diseases. However, there are other factors that remain controversial, and indicators with high predictive sensitivity and accuracy remain deficient. It is important to provide such evidence based on large-scale studies.
In this 3-year project, we aim to 1) explore the risk factors that predispose people to the development of digestive tract disease. 2) identify indicators that can assist with the individualized prediction of digestive tract diseases. Our findings will help the public to take actions, for example, lifestyle modification, to prevent digestive tract diseases, and assist in the decision-making process of healthcare providers.
Research question: The digestive tract is essential in maintaining the function of the human body. Dysfunction and diseases of the organs in the digestive tract (e.g., malformation, inflammation, tumor, etc.), are detrimental and even pernicious. Despite advances in therapeutics, the key to addressing digestive tract diseases is prevention, rather than treatment after diseases occur. Therefore, exploring risk factors and biomarkers for digestive tract diseases is essential. Our research questions are: what are the risk factors that predispose people to digestive tract diseases, and which biomarker can predict digestive tract diseases?
Aims: 1) To explore the risk factors, especially genetic factors that predispose people to the development of digestive tract disease. 2) To identify novel clinical and gene-level biomarkers that can assist with the individualized prediction of digestive tract diseases. 3) To investigate the interactions between the gut and the body. 4) To provide important healthcare-related information to the public, and exert profound impacts on public health.