Approved Research

Core business of the CNV analysis group for the Psychiatric Genomics Consortium

Lay summary

This project will utilize genetic data from the UK Biobank to carry out large scale studies of copy number variation (CNV) in psychiatric disorders. This project will be carried out by the CNV analysis group for the Psychiatric Genomics Consortium. CNV calls will be generated across the full UKBB dataset, and the UKBB data will be combined with existing data from 11 PGC disorders including Autism, ADHD, Bipolar Disorder, Schizophrenia, Major Depression, Tourettes/OCD, PTSD, Substance Use Disorders, Eating disorders, and Alzheimers disease, thereby significantly increasing the numbers of population controls (and cases if diagnosis information is available). The association of CNVs with psychiatric diagnosis will be examined, and the influence of CNVs on cognitive, physiological and anthropometric traits in the general population will be examined.