Approved Research

Effect of long term bisphosphonate therapy on occurrence of severe adverse effects

Lay summary

Bisphosphonates are a class of drug often used to treat osteoporosis, a disease which weakens the bones. However, long-term use of this drug can potentially result in harmful side effects, including femur fracture and death of the jaw bone. While past studies have shown that there is a connection between long-term use of this drug and these adverse effects, there is still uncertainty regarding the ideal duration of treatment to minimize such risks.

The aim of our study is to determine how to most safely treat osteoporosis-driven bone loss while minimizing the occurrence of severe side effects. The research project will use data from the UK biobank to investigate the relationship between different aspects of bisphosphonate treatment, including the type of drug, the length of treatment, and the treatment regimen. This retrospective study design allows us to investigate associations and connections between these variables to identify patterns and risk factors.

Knowledge gained from this study will be important in helping physicians make better treatment plans for patients. By providing evidence-based guidance, we aim to assist healthcare providers in making informed decisions about the duration and management of bisphosphonate therapy, promoting both bone strength and patient safety. Ultimately, our research intends to improve public health by gaining a deeper understanding of how to manage osteoporosis, a disease that affects many globally.