Effects of early-life and later-life nutritional status on multiple disease outcomes: a Mendelian randomization phenome-wide association and mediation study
Aim 1: To elucidate the relationships between the nutritional status and chronic diseases (including cardiovascular diseases, muscular skeletal diseases, and neurological diseases).
scientific rationale 1:
research gap 1: previous studies have not found the relationships and the causal effect between these about the above chronic diseases and nutritional status.
Aim 2: To elucidate the relationships between the nutritional status and the above chronic diseases based on the genetic analysis, including single nucleotide variation and whole genome)
Research gap 2: the genetic evidence between the nutritional status and chronic diseases is limited.
Project duration: 36 months
Public health impact: Understanding the causal relationships between the chronic diseases including cardiovascular diseases, musculoskeletal disease and neurological disease and information based on the genetic factors. Though our findings, we can identify patients at high risk of chronic diseases (cardiovascular disease or stroke, etc.), such as they with a certain genotype and a deficiency in a specific nutrient such as vitamin D in advance. We can earlier supply certain specific nutrients to these patients to achieve the preventive effect of these major chronic diseases and promoting public health.