Approved Research

Effects of environmental, clinical and genetic factors on the morbidity, progression and mortality of chronic kidney disease (CKD)

Lay summary

Chronic kidney disease (CKD) have contributed to most of the health burden. Early detection and prevention are of great significant to clinical practice and policy formulation. Large-scale cohort studies with genetic and imaging data offer extraordinary opportunities to search for new biomarkers and to build the accurate predictive models for morbidity, progression and mortality of CKD. The aims of our studies are: (1) To explore the environmental, clinical and genetic risk factors associated with the morbidity, progression and mortality of CKD. (2) To quantify image data for providing objective evidence to detect disease at an earlier stage. (3) To predict the risk of morbidity, progression and mortality of CKD after incorporate into the genetic high-dimensional data, environmental and clinical factors. (4) To explore the kidney-heart-brain axis from medical imaging influenced by a set of shared risk factors, such as obesity, hypertension, diabetes mellitus, etc. (5) To provide scientific suggestions for the prevention of CKD, improve prognosis of those patients and decrease the health burden as far as possible.

This project duration would be three years. The public health impact would identify novel risk factors and pathological mechanisms to enable precision prevention of CKD and decrease in the health burden.