Approved Research

Environmental and genetic determinants of morbidity and mortality among adults with cardiometabolic disorders

Lay summary

Aims: To investigate the associations of environmental exposure (diet, lifestyle, social psychology, medication, etc.), genetic factors, and their interactions with morbidity and mortality among adults with cardiometabolic disorders (e.g., diabetes, hypertension, and coronary heart disease).

Scientific rationale: An increasing number of people are living with cardiometabolic disorders, including diabetes, hypertension, and coronary heart disease. It is of great importance to identify risk factors for the prevention or delay the cardiometabolic complications and premature death. However, few studies have comprehensively examined the roles of genetic and non-genetic, as well as clinical factors, on the development of cardiometabolic complications and premature death.

Project duration: 36 months.

Public health impact: Using the unique resource of UK biobank, our study will promote the understanding of the etiology of cardiometabolic complications in individuals with cardiometabolic disorders, and will provide scientific evidence for early intervention and better disease management.