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Approved Research

Evaluation of how loss-of-function mutations in pharmacokinetic genes cause drug side effects to happen more often as a person ages.

Principal Investigator: Dr Kyehwa Lee
Approved Research ID: 93501
Approval date: March 10th 2023

Lay summary

The effectiveness and side effects of drugs can differ based on a person's genetic make-up. It is widely accepted that some adverse drug reactions and genetic changes are linked. Everyone with causal genetic abnormalities does not necessarily experience adverse drug effects. This is due to the fact that the likelihood of drug side effects is regulated by gene-gene interaction, gene-environment interaction, and the patient's overall health. It's likely that the human body has defense mechanisms in place to combat the negative effects of foreign drugs. This compensation decreases with age, and the negative outcome may occur more frequently. We want to know if there is an age-related drop in this gene-general health compensation power. As a result, we will first explore whether drug side effects are caused by drug prescription and personal genetic profile. We also find out if the frequency of adverse events changes with age. Using both of these discoveries, we can create an age-gene-drug link function to foresee adverse drug reactions. We expect doctors to be able to modify a prescription based on the patient's age and genetic composition. Individualized therapy could become a reality as a result of this.