Approved Research
Gene-environment interactions in predicting physical and mental health outcomes
Lay summary
In this research project, we aim to explore how our genes and the environment we live in interact to affect our health. We will focus on three important public health issues: the relationship between socioeconomic status (SES) and cardiovascular disease (CVD) risk, mental health outcomes related to stress, and the differences in type 2 diabetes (T2D) prevalence among various ethnic groups. Understanding how our genes and environment work together can help us develop targeted interventions to improve public health.
Aims:
Investigate how gene-environment interactions affect the relationship between SES and CVD risk. We want to identify specific genetic markers and see how they interact with factors related to SES, such as income and education level, to influence CVD risk.
Examine the impact of gene-environment interactions on mental health outcomes, particularly in relation to stress exposure and genetic predisposition to depression and anxiety. We aim to understand how our genes and stressful life events work together to increase the risk of mental health issues.
Explore how gene-environment interactions can help explain differences in T2D prevalence among different ethnic groups. We will look at how genetic factors interact with lifestyle factors, such as diet and physical activity, to influence T2D risk among diverse populations.
Scientific Rationale:
Previous research has shown that health outcomes related to SES, mental health, and T2D can be influenced by both genetic and environmental factors. However, the specific ways in which our genes and environment interact to shape these health outcomes are not well understood. By studying these gene-environment interactions, we can gain valuable insights into the underlying causes of health disparities and develop more effective, targeted interventions.
Project Duration:
This research project is expected to take approximately 3 years to complete. The first year will be dedicated to data preparation and preliminary analyses, while the second and third years will focus on conducting in-depth analyses, interpreting results, and disseminating findings.
Public Health Impact:
The results of this research project have the potential to significantly improve public health by informing the development of targeted interventions and prevention strategies to address health disparities related to SES, mental health, and T2D. By uncovering novel gene-environment interactions, we can help identify high-risk individuals who may benefit from early intervention and personalized treatment approaches. This knowledge can contribute to a more equitable healthcare system and ultimately lead to better health outcomes for all.