Genotypes and phenotypes associated with major adverse cardiovascular events: A phewas study of Southeast and European population
Approved Research ID: 92787
Approval date: December 23rd 2022
Goals and justifications for science.
The UK Biobank serves as a significant resource to study the relationship of human biological traits and risk of developing a disease, such as heart disease. The PheWAS is a powerful research method widely used to identify potential genetic variants that connected to a human disease. Using observational and data modelling analyses, PheWAS results can be used to build a scoring system for calculating the CVD's risk. The scoring system accounts for genetic, biological traits, and demographics, can estimate disease's risk more precisely.
The study's goals are to: (1) identify new genetic and biological factors that affect heart disease's risk; (2) replicate established genetic-biological traits connected to heart disease; (3) investigate molecular mechanism and develop new treatment, and (4) foresee adverse drug reactions related to the treatment.
Public health impact.
This study will increase our understanding of how heart disease develops and provides a personalized approach to treat patient by using an integrative method. A risk score based on a person's genetic-biological trait can help patients receive the most effective treatment by accurately estimating the likelihood whether disease worsen or improve.