Identifying genetic susceptibility factors for developing herpes zoster (HZ).
Approved Research ID: 70885
Approval date: June 16th 2021
Chickenpox is a consequence of infection of varicella-zoster virus (VZV). Afterwards, VZV remains dormant in neurons until awakening which causes the painful rash called shingles. Although we know certain aspects of why 1/3 of the population develops HZ, such as ageing and declining immunity, much remains unknown. Given the familial clustering of HZ, we hypothesize that specific genetic risk factors have an effect on the risk of developing HZ. With this project we would like to identify the genetic susceptibility for HZ. These results might affect the treatment options for this disease.