Impact of pharmacogenomics (PGx) on pharmacotherapy outcomes in a population with chronic disease
Objectives: Exploring the impact of pharmacogenomics (PGx) on drug therapy outcomes in the chronic disease population
Scientific rationale: Genetic traits are one of the major contributors to individual differences in drug responsiveness. The effects of PGx on drug absorption, distribution, metabolism, excretion, and adverse effects are well studied, and many organizations have published recommendations for PGx to guide clinical usage of drugs. However, there is still a paucity of research on the impact of PGx on treatment outcomes.
Project duration: 36 months
Public health impact: This study will clarify whether there is an effect of PGx on the outcome of medication for chronic diseases, which will support the application of PGx in the clinic and promote precision treatments in chronic disease population.