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Approved Research

Integrative Neurobiological Bases of Brain Aging in Late Life

Principal Investigator: Professor Randy Buckner
Approved Research ID: 67237
Approval date: January 25th 2021

Lay summary

Even in the absence of neurodegenerative disorders like dementia or Alzheimer's disorder, aging is associated with changes in the brain as well as deficits in cognitive ability. However, brain aging does not occur at the same pace or in the same way for all individuals. Some may age "optimally" with little to no changes in memory or cognition, while others may experience severe forms of impairment. This project aims to identify factors that are most important for maintaining brain health through late adulthood. We will study individual differences in genetics, lifestyle, and environment in combination with measures of brain shape, size and function. By characterizing which factors are most important for promoting longevity, this work will help craft public health policy and identify specific biological targets for medical research and intervention. This study is expected to last a minimum of three years (2020-2023).