Approved Research

Investigation of the causal relationship between inflammatory skin diseases and dementia using Mendelian randomization analysis of UK Biobank data

Lay summary

This research project aims to explore the connection between atopic dermatitis and psoriasis, and the risk of developing dementia. By investigating whether these skin conditions have a direct impact on dementia or share common risk factors, we hope to shed light on the relationship between inflammatory skin diseases and dementia.

Inflammatory skin diseases have been associated with an increased risk of dementia in previous studies. However, it is not yet clear whether these conditions cause dementia or if other factors are involved. To unravel this mystery, we will employ an innovative research approach called Mendelian randomization analysis.

Mendelian randomization analysis will allow us to investigate whether there is a causal relationship between inflammatory skin diseases and dementia. By analyzing genetic data from the UK Biobank, a large study involving thousands of participants, we will identify genetic markers associated with inflammatory skin diseases. These genetic markers will serve as clues to understand the potential impact of inflammatory skin conditions on the risk of developing dementia.

The findings of this research have significant implications for public health. By establishing a causal link between inflammatory skin diseases and dementia, this study could shed light to the importance of early detection and effective management of these skin conditions. By addressing inflammatory skin diseases, we may be able to reduce the risk of developing dementia later in life. Moreover, understanding the underlying mechanisms connecting these diseases can pave the way for the development of new preventive measures and treatments for dementia. By deciphering how inflammatory processes in the skin may contribute to cognitive decline, we can potentially identify novel targets for intervention and improve the overall management of dementia.

This research project is estimated to span approximately 36 months. Our team will meticulously analyze the data from the UK Biobank and communicate our findings through scientific publications and academic meetings. Our goal is to ensure that the broader public can benefit from the knowledge gained through this study and contribute to the advancement of dementia research and care. By investigating the intricate relationship between inflammatory skin diseases and dementia, this study has the potential to deepen our understanding of the risk factors associated with dementia and make strides toward preventing and managing this debilitating condition.