Approved Research

Multi-omics and Epidemiology Approaches for Elucidating the Mechanisms of Immune-Mediated Inflammatory Diseases

Lay summary

The research project aims to delve into the factors involved in immune-mediated inflammatory diseases (IMIDs) and their impact on disease development, progression, and treatment outcomes. By studying various biological factors at a molecular level, such as genetics, epigenetics, proteins, and metabolites, the project seeks to unravel the complex mechanisms underlying IMIDs. Additionally, the research aims to understand how these factors interact with environmental and lifestyle influences. The ultimate goal is to improve diagnostics, treatments, and personalised medicine approaches for IMIDs.

The scientific rationale for this project stems from the fact that IMIDs, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease have a significant impact on patients' lives and healthcare systems worldwide. Despite extensive research, our understanding of the precise mechanisms underlying these diseases remains limited. By harnessing the power of advanced multi-omics technologies and integrating them with epidemiological data from the UK Biobank, we will gain valuable insights into the molecular intricacies of IMIDs and their interactions with environmental factors.

In the period of 36 months, we aim to identify key molecular pathways and biological processes associated with IMID development and progression, and potentially develop improved diagnostic tools and predictive biomarkers. This can lead to earlier detection of IMIDs and more personalised treatment strategies, ultimately improving patient outcomes. Moreover, by considering gene-environment interactions and modifiable risk factors, the research may uncover opportunities for preventive measures to reduce the incidence and burden of IMIDs.