Approved Research

Multidimensional study on risk factors and related prevention and control measures for non-communicable diseases

Lay summary

Aims: The proposed project aims to clarify the potential risk factors for NCD by multiple dimensions, and to study NCD-related proteins to prioritize drug targets and provide insights into the molecular mechanisms of complex clinical syndromes.

Scientific rationale: In recent decades, with the rising socioeconomic development and urbanization, the risk of non-communicable diseases (NCDs) in the population is increasing, including cancer, diabetes, obesity, atherosclerosis, and non-alcoholic fatty liver disease. To address the impact of the NCD burden, countries have committed to achieving the global NCD targets, including the sustainable development goal of reducing premature NCD deaths by one-third by 2030. As it stands, one of the most important and economically feasible ways to reduce NCD deaths is to control the risk factors that contribute to their development. NCDs are influenced by a variety of factors, including genetics, environmental factors (diet/ nutrients, lifestyle, metabolic status, and atmospheric pollution), and psychosocial conditions. Clarifying the impact of these risk factors on NCDs individually or in combination will help assess modifiable risks and will be essential for individualized prevention and treatment measures. In addition, we hope to study NCD-related proteins, prioritize drug targets, and provide insights into the molecular mechanisms of complex clinical syndromes.

Project duration: This project is expected to be completed in 36 months.

Public health impact: We believe that the results in this project will provide a broader understanding of the causative factors and possible mechanisms of NCDs, identify therapeutic targets, contribute to targeted interventions and prognostic measures, achieve precision medicine, and will help reduce the future burden of NCDs on individuals and society.