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Approved Research

Rare variant contribution to human Parkinson's disease

Principal Investigator: Professor laixin Xia
Approved Research ID: 81596
Approval date: April 12th 2022

Lay summary

Neurodegenerative disease is a severe disease caused by the degeneration or apoptosis of neurons which threatens patients' health and lay a burden on their families. Parkinson's disease (PD) is clinically prominent neurodegenerative disease. Although researchers have proposed several hypotheses, the cause is still unclear.

There are lots of difficulties in early diagnosis. When patients with relative disorder were diagnosed with PD, the progression of the disease could not be stopped any more. Many patients have family history of PD. We aim to find rare variants contribute to PD to identify the population at high risk of this disease. This finding would be conducive to early diagnosis and preventing disease development.

Our current research is primarily focused on Parkinson's disease (PD), a prominent neurodegenerative disease. Our aim has been to identify rare variants that contribute to PD, with the goal of identifying populations at high risk and facilitating early diagnosis and prevention.

As our research has progressed, we have identified a compelling need to broaden our scope to encompass a wider range of degenerative diseases and to investigate gene-environment interactions. This expansion will facilitate a comprehensive exploration of these discoveries, furthering our understanding of the genetic landscape of degenerative diseases and the complex interplay of genetic and environmental factors.