Risk Factors and Health Consequences of Cerebral White Matter Hyperintensity
Principal Investigator: Professor Wei Wen
Approved Research ID: 37103
Approval date: October 24th 2018
White matter hyperintensity (WMH) as observed in T2-weighted MRI scan is considered as pathologies related to cerebrovascular disease which is a leading cause of morbidity and mortality with manifold clinical consequences including stroke, depression and various neuropsychiatric symptoms. Our focus is on the association of WMH with clinical data, cognitive disorders, including dementia and genetics. WMH is markedly pleomorphic. There is an unmet need to better quantify WMH burden and relate it to clinical data, cognition, and genetics. Recent advances in MRI allow the imaging and quantification of different forms of WMH. Our research aim is to investigate and identify the risk factors for WMH; and examine the associations between WMH and health outcomes.