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Approved Research

Risk factors for cardiovascular morbidity and mortality in postmenopausal women

Principal Investigator: Professor Jose Quesada
Approved Research ID: 77679
Approval date: January 25th 2022

Lay summary

The presentation of cardiovascular disease is different between men and women (risk factors, presentation, diagnosis and treatment).In addition, it is known that women are not equally represented as men in cardiovascular risk studies. In fact, it has been shown that women with cardiovascular disease is later diagnosed than men. The therapeutic results are also lower in women than men. On the other hand, cardiovascular risk increases during menopause, so the risk factors specific to women should be considered by the medical and scientific community in cardiovascular prevention. Thus, to reduce this inequality, it is necessary to study the women independently, with their own markers and risk factors.

This study aims to explore the risk factors of cardiovascular morbidity and mortality in postmenopausal women exclusively. The project duration will be one year.

Scope extension:

General objective:

To evaluate the risk factors, exclusive of postmenopausal women, for the incidence of cardiovascular morbidity and mortality.

Specific objectives:

  1. Evaluate the specific cardiovascular risk posed by surgical menopause (hysterectomy) versus natural menopause.
  2. Evaluate the specific cardiovascular risk that the age of menopause contributes.
  3. To evaluate the specific cardiovascular effect of hormonal treatment in postmenopausal women.

Secondary objectives:

  1. To determine the proportion of postmenopausal women who suffer a cardiovascular event and do not receive the treatment recommended by clinical practice guidelines (therapeutic inertia) during admission or discharge.
  2. Analyze the diagnostic inertia of the main traditional risk factors (dyslipidemia, diabetes, hypertension) in postmenopausal women.
  3. To develop an exclusive cardiovascular risk predictor tool for postmenopausal women, taking into account the factors of the female sex.


We want to add a secondary objetive:

- To validate the SCORE2 scale for the estimation of cardiovascular risk in the cohort of postmenopausal women, and to assess its predictive capacity.