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Approved Research

Systematic evaluation of factors associated with physical, mental and social well-being

Principal Investigator: Dr Xiaoxin Iris Yao
Approved Research ID: 79263
Approval date: April 28th 2022

Lay summary

The World Health Organization (WHO) established the definition of health as a state of physical, mental and social well-being several decades ago. Many studies have examined determinants of these dimensions of health individually, but little empirical research has operationalized them as a triaxial concept. We seek to identify key factors associated simultaneously with physical, mental and social well-being, according to the WHO definition, in this longitudinal, multivariate environment-wide association study (EWAS). This agnostic approach evaluating all available associations, irrespective of prior knowledge, is particularly relevant here given the lack of theoretical models.

Project duration: three years

Public health impact: The determinants found in this study, if verified to be causal, could be prioritized as intervention targets to holistically improve population health.