Approved Research

The association between cardiac dysfunction and novel risk factors in chronic kidney disease

Lay summary

Aims

Investigate the factors of prognosis in patients complicated with chronic kidney disease and cardiovascular disease at the aspect of gene, molecule, laboratory and auxiliary examination, so that to improve the preventive strategies and elucidate new therapeutic targets.

scientific rationale

Chronic kidney disease (CKD) is a major public health issue that affects millions of people worldwide and is associated with a higher risk of developing cardiovascular diseases. In patients with CKD, coronary artery disease and heart failure are the major cardiovascular disease and account for the worse prognosis. However, there is little evidence regarding the risk factors and preventive targets of adverse prognosis in patients with chronic kidney disease and cardiovascular disease at the aspect of gene and molecule.

We are planning to identify the genes or molecules which would potentially correlate with the development and progression of chronic kidney disease and cardiovascular disease with data from the UK biobank. The factors of interaction between chronic kidney disease and cardiovascular disease are also included in the research plan in order to obtain the potential heart and kidney-related genes and clarify their association. Furthermore, we would try to reveal the potential biomarkers for subsequent research and treatment.

Expected duration of the project

  36 months.

public health impact of work

In this study, we would demonstrate that CKD affects the development and progression of cardiovascular disease through different factors in addition to the traditional cardiovascular risk factors. Moreover, we would also demonstrate the mechanism of how chronic kidney disease would cause cardiovascular disease at the novel aspect of genes and molecules, so that to explore new targets and strategies for the treatment and prevention of cardiovascular disease at the early stage.